石富国，博士，教授，博导，毕业于中国药科大学药物分析学专业，获理学博士学位。从事药物代谢动力学和毒理学研究。国家自然科学基金同行评议专家。中国药理学会药物代谢委员会青年委员。主持国家自然科学基金4项、贵州省科学技术基金重点项目1项、一般项目2项。入选贵州省高层次创新型人才（千层次）和永利yl23411官网优秀青年人才。为Archive of Toxicology, Journal of pharmaceutical and biomedical analysis等期刊审稿人。以第一作者或通讯作者在DMD、BCP、JCA等期刊发表SCI论文二十余篇。
主要从事药物代谢动力学和毒理学研究，包括药代动力学性质评价及优化、参与疾病发生的药物/内源性物质转化代谢和作用模式研究。
1国家自然科学基金青年项目，基于质谱法的多巴胺反应性氧化产物蛋白加合物定量分析，2017/01-2019/12，主持
2贵州省科学技术基金项目， 基于药物代谢动力学性质的淫羊藿素结构修饰与药效学评价 2017/01-2019/12，主持
3 贵州省科学技术基金项目, 以代谢激活理论为导向的白鲜皮肝损伤成分发现研究 2018/01- 2020/12，主持。
4 遵义医学院优秀青年人才项目青年优秀人才层次 2019/1-2023/12，主持。
5 国家自然科学基金地区项目，基于代谢激活理论的白鲜皮肝损伤机制研究2020/1-2023/12，主持。
6国家自然科学基金地区项目，基于重塑肠道菌群功能的环烯醚萜苷改善胆汁淤积性肝损伤机制研究2022/1-2025/12，主持。
7贵州省（第六批）高层次创新型人才“千层次”，2022年。
8 国家自然科学基金地区项目，多巴胺能神经醛超载的全景分析及在帕金森病中的致病机制研究 2025/01-2028/12 ，主持。
9贵州省基础研究计划重点项目， 帕金森动物模型中α-突触核蛋白的赖氨酸共价修饰物和修饰位点研究2025/01-2028/12 ，主持。
1 Xiaoli Li, Zejun Liu, Qi Luo, Hong Pan, Fuguo Shi* Structural feature-based comprehensive characterization of diterpenoid alkaloids of fermented Aconitum carmichaelii Debx in rats by UPLC-Q-Orbitrap MS. Journal of Chromatography A 2025
2 Hong Pan, Qi Luo, Qiuyi Jing, Lin Chen, Ni Li, Chao Fang, Fuguo Shi*. Multiple endogenous aldehydes amplify acetaminophen-induced liver injury. Chemico-Biological Interactions 2025
3 Hong Pan, Yang Shen, Guohong Zhai, Xiaobing Li, Qin Wu, Chao Fang, Jingshan Shi*, Fuguo Shi*. Enterogastric and enterohepatic recycling of dendrobine in rats: a novel disposition mechanism responsible for pharmacokinetic multiple peaks. Biochemical Pharmacology. 2025.
4 Qiuyi Jing, Hong Pan, Xiaoli Li, Yaya Fan, Jingshan Shi, Chao Fang, Fuguo Shi* Covalent protein modification by multiple reactive dialdehyde metabolites of catalpol via intestinal bioactivation. Journal of Pharmaceutical and Biomedical Analysis. 2025
5 Hong Pan, Guohong Zhai, Qiuyi Jing, Yaya Fan, Chao Fang, Fuguo Shi*.Two-step metabolic activation to ortho-benzoquinone intermediate and its role in 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside-induced liver injury. Drug Metabolism and Disposition 2025
6 Yaya Fan, Lin Chen, Qiuyi Jing, Xiaoli Li, Hong Pan, Chao Fang, Jianyong Zhang*, Fuguo Shi**. Covalent binding of reactive anhydride of cantharidin to biological amines. Drug Metabolism and Disposition. 2024
7 Qi Luo, Yang Shen, Guohong Zhai, Lin Chen, Furong Ou, Luxi Yi, Danli Yang, Hong Pan, Fuguo Shi*. Role of covalent modification by hepatic aldehydes in dictamnine-induced liver injury. Toxicology Letters. 2024
8 Zejun Liu, Xiaoli Li, Qi Luo, Hong Pan, Fuguo Shi*. Structural feature-based strategy for the identification of diterpene alkaloids in Aconitum carmichaeli Debeaux. Fitoterapia. 2023
9 Junli Jin, Qi Luo, Fuguo Shi*. Identification of intestinal metabolic activation of loganin generated dialdehyde reactive intermediates improves intestinal bile salt hydrolase activities. Journal of Chromatography B. 2023
10 Lin Chen, Hong Pan, Guohong Zhai, Qi Luo, Yi Li, Chao Fang, Fuguo Shi*. Widespread occurrence of in-source fragmentation in the analysis of natural compounds by liquid chromatography-electrospray ionization mass spectrometry. Rapid Communication Mass Spectrometry. 2023.
11 Hong Pan, Lin Chen, Guohong Zhai, Qi Luo, Chao Fang, Fuguo Shi*, Feature MS fragments-based method for identification of toxic furanoids in biological samples Journal of Pharmaceutical and Biomedical Analysis. 2022
12 Kaili Wu, Hong Pan, Yi Li, Linyan Huang, Chao Fang, Fuguo Shi*. The protein adduction derived from reactive metabolites of multiple furanoids in Cortex Dictamni-treated mice. Toxicology Letters. 2022
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